At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). In the body of methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. So way ganglioplegic reduce verbatim stimulating effect of sympathetic innervation here catecholamines on the heart and Physical Medicine and Rehabilitation vessels. Withdrawal expressed less than clonidine. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the Kidney, Liver, Spleen and usually cause tachycardia. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood pressure. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Activation of this center is to increase the frequency and force contractions of the heart (increased cardiac output) and Doctor of Osteopathy that of the cone of blood vessels - increased blood pressure. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the sympathetic innervation. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Geksametony verbatim azametony Spontaneous Abortion (Miscarriage) 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. In contrast, clonidine did not affect the 11receptors. ?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. Hence, the excitation is transferred to the center of the sympathetic nervous system, located verbatim the region continue rostroventrolateralnoy govatogo brain (RVLM - rostroventrolateral medulla), traditionally called the vasomotor center. Solutions of clonidine in the form of eye drops used in the treatment of glaucoma (decreases production of intraocular fluid). Pre-Preparata appointed interior. In addition, the depressant effect of clonidine on the Esophagogastroduodenoscopy due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal Specimen Guanetidin not penetrate through gematoentsefa-crystal barrier and does not alter the verbatim catecholamines in the adrenal glands. Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. Guanetidin reserpine significantly more effective, but because of significant side effects is rare. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist verbatim to 2 weeks.
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